Linked Life Data

21029400

Source:http://linkedlifedata.com/resource/pubmed/id/21029400

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-12
pubmed:abstractText
Recent European guidelines facilitate the use of emergency vaccines during outbreaks of foot-and-mouth disease. Antiviral drugs could be used as a complementary measure. This study aimed at developing a small animal model to assess the in vivo activity of early antiviral lead molecules with anti-foot-and-mouth disease virus (FMDV) activity in vitro. In a first attempt, several FMDV strains were titrated in Balb/c mice. Inoculations with O? Manisa or C? Noville did not induce clinical disease, whereas Asia1 Shamir induced death too rapidly [i.e. within 4 days post-inoculation (dpi)]. Therefore, we switched to severe combined immunodeficient mice which are frequently used as a model for viral infections and experimental therapeutics. Strain O? Manisa did not induce clinical disease, but titrations with A?? Iraq, C? Noville or Asia1 Shamir resulted in virus-induced morbidity (including respiratory problems and weight loss) with subsequent mortality. Inoculations with strain A?? Iraq resulted in a reproducible mean time of death of 6 dpi (this was shorter for the other strains). In this newly developed rodent model, strain A?? Iraq seems the most suited to assess the in vivo anti-FMDV activity of selective inhibitors of FMDV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1865-1682
pubmed:author
pubmed:copyrightInfo
© 2010 Blackwell Verlag GmbH.
pubmed:issnType
Electronic
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
430-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs.
pubmed:affiliation
Unit of Vesicular and Exotic Diseases, Virology Department, CODA-CERVA-VAR, Veterinary and Agrochemical Research Centre, Groeselenberg, Brussel, Belgium. dalef@var.fgov.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't