Linked Life Data

21028891

Source:http://linkedlifedata.com/resource/pubmed/id/21028891

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-29
pubmed:abstractText
Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC(50) values of 11 and 0.21 ?M, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1943-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.
pubmed:affiliation
Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't