Linked Life Data

2102021

Source:http://linkedlifedata.com/resource/pubmed/id/2102021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-9-13
pubmed:abstractText
The development of a vaccine against schistosomiasis is necessary in order to reduce the risk of reinfection after drug treatment. Recent reports converge on a message strongly supporting the existence of naturally acquired human immunity to this infection and reinforcing the hypothesis that at least partial protection can be achieved by artificial means. Advances in molecular biology have led to the identification and characterization of an array of protective schistosome antigens, and the introduction of new sophisticated methods for their production enables a bypass of previous low-yielding and labour-intensive procedures. Although vaccination of animals with these antigens does not result in consistent levels of protection exceeding 50%, the reproducible induction of about 80% protection with live attenuated cercariae indicates that immunization against schistosomiasis is achievable. The finding of antibodies capable of blocking protective immunological responses suggests a complicated interaction between different properties of the immune system which needs to be understood and modulated in the direction of improved resistance. An overview of the present status of vaccine development in schistosomiasis including results in different animal models and evidence from field studies on humans is presented and discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8878
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-71
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Prospects of vaccination against schistosomiasis.
pubmed:affiliation
UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland.
pubmed:publicationType
Journal Article, Review