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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8-12
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pubmed:dateCreated |
1991-8-26
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pubmed:abstractText |
Keto and enol tautomers of chlortetracycline and 4-epichlortetracycline were successfully separated by low temperature high-performance liquid chromatography on poly(styrene-divinylbenzene)copolymer. The keto-enol tautomerism occurs between C-11a and C-12. The elucidation of the chemical structure of the tautomers was realized with the help of on-line and off-line UV-spectrophotometry and of 13C and 1H NMR spectrometry. The kinetics of the equilibrium reaction were investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0731-7085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
881-9
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:2100637-Buffers,
pubmed-meshheading:2100637-Chlortetracycline,
pubmed-meshheading:2100637-Chromatography, High Pressure Liquid,
pubmed-meshheading:2100637-Hydrogen-Ion Concentration,
pubmed-meshheading:2100637-Indicators and Reagents,
pubmed-meshheading:2100637-Isomerism,
pubmed-meshheading:2100637-Kinetics,
pubmed-meshheading:2100637-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2100637-Polystyrenes,
pubmed-meshheading:2100637-Spectrophotometry, Ultraviolet,
pubmed-meshheading:2100637-Stereoisomerism,
pubmed-meshheading:2100637-Temperature
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pubmed:year |
1990
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pubmed:articleTitle |
Separation of keto-enol tautomers of chlortetracycline and 4-epichlortetracycline by liquid chromatography on poly(styrene-divinylbenzene)copolymer.
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pubmed:affiliation |
Katholieke Universiteit Leuven, Instituut voor Farmaceutische Wetenschappen, Belgium.
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pubmed:publicationType |
Journal Article
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