Linked Life Data

209983

Source:http://linkedlifedata.com/resource/pubmed/id/209983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-10-27
pubmed:abstractText
In a series of polybrominated biphenyl (PBB) feeding trials in White Leghorn cockerel chicks, the effects of PBB on various physiological parameters and organ weights were determined. These measurements included: growth, thyroid function, ECG, cardiac output, blood pressure, hematocrit, erythropoietin levels, and spleen, bursa of Fabricius, thyroid, testes, comb, liver weights. In addition, tissues were histologically examined. PBB, in the commercial grade form of hexabromobiphenyl, was administered continuously in the diet at levels ranging from 50 to 250 ppm. Pair-feeding studies were conducted to ascertain the effects of the drug per se since preliminary trials indicated that PBB administration resulted in decreased feed intake. Chronic administration resulted in depressed body weight as a result of decreased feed intake; decreased comb, testes, spleen, and bursa weights; increased liver and thyroid weight; hydropericardium and ascites; decreased hematological values due to depressed plasma erythropietin levels; decreased heart rate, packed cell volume, hemoglobin and cardiac output; decreased voltage amplitude of the ECG and a shift in the mean electrical axis. No significant differences were found in blood pressure (mean arterial and pulse pressure), stroke volume, or respiratory rate.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0091-6765
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-55
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
PBB fed to immature chickens: its effect on organ weights and function and on the cardiovascular system.
pubmed:publicationType
Journal Article