Source:http://linkedlifedata.com/resource/pubmed/id/20981332
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-10-28
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| pubmed:abstractText |
A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic ?Fe(2)O(3) nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRI T2(?) contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show that ?Fe(2)O(3)@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
2042-0064
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
2010
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
747852
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| pubmed:year |
2010
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| pubmed:articleTitle |
Superparamagnetic bifunctional bisphosphonates nanoparticles: a potential MRI contrast agent for osteoporosis therapy and diagnostic.
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| pubmed:affiliation |
Laboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, France.
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| pubmed:publicationType |
Journal Article
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