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pubmed-article:20980462pubmed:abstractTextThe islet in type 2 diabetes is characterized by ?-cell apoptosis, ?-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in ?-cells in humans with type 2 diabetes, suggesting impaired clearance of misfolded proteins. In this study, we investigated whether human-IAPP (h-IAPP) disrupts the endoplasmic reticulum-associated degradation/ubiquitin/proteasome system.lld:pubmed
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pubmed-article:20980462pubmed:articleTitle?-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.lld:pubmed
pubmed-article:20980462pubmed:affiliationLarry Hillblom Islet Research Center, University of California, Los Angeles, USA. scostes@mednet.ucla.edulld:pubmed
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