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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
The islet in type 2 diabetes is characterized by ?-cell apoptosis, ?-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in ?-cells in humans with type 2 diabetes, suggesting impaired clearance of misfolded proteins. In this study, we investigated whether human-IAPP (h-IAPP) disrupts the endoplasmic reticulum-associated degradation/ubiquitin/proteasome system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-38
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20980462-Animals,
pubmed-meshheading:20980462-Autopsy,
pubmed-meshheading:20980462-Diabetes Mellitus, Type 2,
pubmed-meshheading:20980462-Humans,
pubmed-meshheading:20980462-Hypoglycemic Agents,
pubmed-meshheading:20980462-Insulin,
pubmed-meshheading:20980462-Insulin-Secreting Cells,
pubmed-meshheading:20980462-Islet Amyloid Polypeptide,
pubmed-meshheading:20980462-Nuclear Proteins,
pubmed-meshheading:20980462-Obesity,
pubmed-meshheading:20980462-Proteasome Endopeptidase Complex,
pubmed-meshheading:20980462-Rats,
pubmed-meshheading:20980462-Rats, Transgenic,
pubmed-meshheading:20980462-Ubiquitin,
pubmed-meshheading:20980462-Ubiquitin Thiolesterase
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pubmed:year |
2011
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pubmed:articleTitle |
?-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.
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pubmed:affiliation |
Larry Hillblom Islet Research Center, University of California, Los Angeles, USA. scostes@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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