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rdf:type |
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lifeskim:mentions |
umls-concept:C0003313,
umls-concept:C0011854,
umls-concept:C0023823,
umls-concept:C0205179,
umls-concept:C0205217,
umls-concept:C0332281,
umls-concept:C0348035,
umls-concept:C0441889,
umls-concept:C0444930,
umls-concept:C0449258,
umls-concept:C0598528,
umls-concept:C0741968,
umls-concept:C1280412
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
High cholesterol levels in circulating immune complexes (IC), surrogate markers of modified LDL, are associated with increased carotid intima-media thickness (IMT) and cardiovascular events in type 1 diabetes. Different modifications of LDL are involved in IC formation, but which of these are predictive of vascular events is not known. Therefore, we measured oxidized LDL (oxLDL), advanced glycation end products-modified LDL (AGE-LDL), and malondialdehyde-modified LDL (MDA-LDL) in IC and determined their relationship with increased carotid IMT and compared the strength of the association with that observed with conventional risk factors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
582-9
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pubmed:meshHeading |
pubmed-meshheading:20980456-Adult,
pubmed-meshheading:20980456-Antigen-Antibody Complex,
pubmed-meshheading:20980456-Carotid Arteries,
pubmed-meshheading:20980456-Diabetes Mellitus, Type 1,
pubmed-meshheading:20980456-Disease Progression,
pubmed-meshheading:20980456-Female,
pubmed-meshheading:20980456-Glycosylation End Products, Advanced,
pubmed-meshheading:20980456-Humans,
pubmed-meshheading:20980456-Lipoproteins, LDL,
pubmed-meshheading:20980456-Logistic Models,
pubmed-meshheading:20980456-Male,
pubmed-meshheading:20980456-Malondialdehyde,
pubmed-meshheading:20980456-Risk Factors,
pubmed-meshheading:20980456-Tunica Intima,
pubmed-meshheading:20980456-Tunica Media
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pubmed:year |
2011
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pubmed:articleTitle |
Levels of oxidized LDL and advanced glycation end products-modified LDL in circulating immune complexes are strongly associated with increased levels of carotid intima-media thickness and its progression in type 1 diabetes.
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pubmed:affiliation |
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. virellam@musc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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