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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
The AMP-activated protein kinase (AMPK) pathway is a master regulator in energy metabolism and may be related to cancer. In type 2 diabetes, low HDL cholesterol predicts cancer, whereas metformin usage is associated with reduced cancer risk. Both metformin and apolipoprotein A1 activate the AMPK signaling pathway. We hypothesize that the anticancer effects of metformin may be particularly evident in type 2 diabetic patients with low HDL cholesterol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1935-5548
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-80
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pubmed:meshHeading |
pubmed-meshheading:20980414-Adult,
pubmed-meshheading:20980414-Aged,
pubmed-meshheading:20980414-Cholesterol, HDL,
pubmed-meshheading:20980414-Diabetes Mellitus, Type 2,
pubmed-meshheading:20980414-Female,
pubmed-meshheading:20980414-Follow-Up Studies,
pubmed-meshheading:20980414-Hong Kong,
pubmed-meshheading:20980414-Humans,
pubmed-meshheading:20980414-Hypoglycemic Agents,
pubmed-meshheading:20980414-Male,
pubmed-meshheading:20980414-Medical Staff, Hospital,
pubmed-meshheading:20980414-Metformin,
pubmed-meshheading:20980414-Middle Aged,
pubmed-meshheading:20980414-Neoplasms,
pubmed-meshheading:20980414-Predictive Value of Tests,
pubmed-meshheading:20980414-Risk Factors,
pubmed-meshheading:20980414-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry.
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pubmed:affiliation |
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. yang.xilin@cuhk.edu.hk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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