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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
The EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion-type tyrosine kinase is an oncoprotein found in 4 to 5% of non-small-cell lung cancers, and clinical trials of specific inhibitors of ALK for the treatment of such tumors are currently under way. Here, we report the discovery of two secondary mutations within the kinase domain of EML4-ALK in tumor cells isolated from a patient during the relapse phase of treatment with an ALK inhibitor. Each mutation developed independently in subclones of the tumor and conferred marked resistance to two different ALK inhibitors. (Funded by the Ministry of Health, Labor, and Welfare of Japan, and others.).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/EML4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/anaplastic lymphoma kinase,
http://linkedlifedata.com/resource/pubmed/chemical/crizotinib
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:ALK Lung Cancer Study Group,
pubmed-author:ChoiYoung LimYL,
pubmed-author:HamadaToruT,
pubmed-author:HarutaHidenoriH,
pubmed-author:IshikawaYuichiY,
pubmed-author:KimuraHidekiH,
pubmed-author:ManoHiroyukiH,
pubmed-author:MitsudomiTetsuyaT,
pubmed-author:NakajimaTakahiroT,
pubmed-author:SodaManabuM,
pubmed-author:TakashimaJunpeiJ,
pubmed-author:TakeuchiKengoK,
pubmed-author:TanioYoshiroY,
pubmed-author:UenoToshihideT,
pubmed-author:YamashitaYoshihiroY,
pubmed-author:YatabeYasushiY
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
363
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1734-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20979473-Adenocarcinoma,
pubmed-meshheading:20979473-Adult,
pubmed-meshheading:20979473-Cell Cycle Proteins,
pubmed-meshheading:20979473-DNA, Complementary,
pubmed-meshheading:20979473-DNA, Neoplasm,
pubmed-meshheading:20979473-Drug Resistance, Neoplasm,
pubmed-meshheading:20979473-Humans,
pubmed-meshheading:20979473-Lung Neoplasms,
pubmed-meshheading:20979473-Male,
pubmed-meshheading:20979473-Microtubule-Associated Proteins,
pubmed-meshheading:20979473-Molecular Structure,
pubmed-meshheading:20979473-Mutation,
pubmed-meshheading:20979473-Protein Kinase Inhibitors,
pubmed-meshheading:20979473-Protein-Tyrosine Kinases,
pubmed-meshheading:20979473-Pyrazoles,
pubmed-meshheading:20979473-Pyridines,
pubmed-meshheading:20979473-RNA, Neoplasm,
pubmed-meshheading:20979473-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:20979473-Sequence Analysis, DNA,
pubmed-meshheading:20979473-Serine Endopeptidases
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pubmed:year |
2010
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pubmed:articleTitle |
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.
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pubmed:affiliation |
Division of Functional Genomics, Jichi Medical University, Tochigi, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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