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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-10-28
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pubmed:databankReference |
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pubmed:abstractText |
Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately half of IMTs carry rearrangements of the anaplastic lymphoma kinase (ALK) locus on chromosome 2p23, causing aberrant ALK expression. We report a sustained partial response to the ALK inhibitor crizotinib (PF-02341066, Pfizer) in a patient with ALK-translocated IMT, as compared with no observed activity in another patient without the ALK translocation. These results support the dependence of ALK-rearranged tumors on ALK-mediated signaling and suggest a therapeutic strategy for genomically identified patients with the aggressive form of this soft-tissue tumor. (Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-10383129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-10655437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-10934137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-10934142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-11406658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-11684952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-12661011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-14645423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17151364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17414097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-1746682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17625570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17660712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17826515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-17938159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-18089725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-18483355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-19275511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-19459784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-19692680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-20979469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-20979477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-21155181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-21345112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-2239820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20979472-7611533
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/MET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/anaplastic lymphoma kinase,
http://linkedlifedata.com/resource/pubmed/chemical/crizotinib
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:AntonescuCristina RCR,
pubmed-author:ButrynskiJames EJE,
pubmed-author:CapellettiMarziaM,
pubmed-author:ChristensenJames GJG,
pubmed-author:ClarkJeffrey WJW,
pubmed-author:D'AdamoDavid RDR,
pubmed-author:Dal CinPaolaP,
pubmed-author:DemetriGeorge DGD,
pubmed-author:HornickJason LJL,
pubmed-author:JännePasi APA,
pubmed-author:JhanwarSuresh CSC,
pubmed-author:KwakEunice LEL,
pubmed-author:LadanyiMarcM,
pubmed-author:MakiRobert GRG,
pubmed-author:RamaiyaNikhilN,
pubmed-author:RodigScott JSJ,
pubmed-author:ShapiroGeoffrey IGI,
pubmed-author:WilnerKeith DKD
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
363
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1727-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20979472-Abdominal Neoplasms,
pubmed-meshheading:20979472-Adult,
pubmed-meshheading:20979472-Granuloma, Plasma Cell,
pubmed-meshheading:20979472-Humans,
pubmed-meshheading:20979472-Male,
pubmed-meshheading:20979472-Mutation,
pubmed-meshheading:20979472-Neoplasms, Muscle Tissue,
pubmed-meshheading:20979472-Protein Kinase Inhibitors,
pubmed-meshheading:20979472-Protein-Tyrosine Kinases,
pubmed-meshheading:20979472-Proto-Oncogene Proteins c-met,
pubmed-meshheading:20979472-Pyrazoles,
pubmed-meshheading:20979472-Pyridines,
pubmed-meshheading:20979472-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:20979472-Receptors, Growth Factor,
pubmed-meshheading:20979472-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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