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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
Glycosylation with ?-N-acetylglucosamine (O-GlcNAcylation) is one of the most complex post-translational modifications. The cycling of O-GlcNAc is controlled by two enzymes: UDP-NAc transferase (OGT) and O-GlcNAcase (OGA). We recently reported that endothelin-1 (ET-1) augments vascular levels of O-GlcNAcylated proteins. Here we tested the hypothesis that O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
614-22
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pubmed:meshHeading |
pubmed-meshheading:20978008-Acetylglucosamine,
pubmed-meshheading:20978008-Acylation,
pubmed-meshheading:20978008-Animals,
pubmed-meshheading:20978008-Aorta, Thoracic,
pubmed-meshheading:20978008-Cardiovascular Diseases,
pubmed-meshheading:20978008-Cells, Cultured,
pubmed-meshheading:20978008-Endothelin-1,
pubmed-meshheading:20978008-Male,
pubmed-meshheading:20978008-Muscle, Smooth, Vascular,
pubmed-meshheading:20978008-Phosphorylation,
pubmed-meshheading:20978008-Rats,
pubmed-meshheading:20978008-Rats, Wistar,
pubmed-meshheading:20978008-Signal Transduction,
pubmed-meshheading:20978008-Vasoconstriction,
pubmed-meshheading:20978008-rho-Associated Kinases,
pubmed-meshheading:20978008-rhoA GTP-Binding Protein
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pubmed:year |
2011
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pubmed:articleTitle |
O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway.
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pubmed:affiliation |
Department of Physiology, Medical College of Georgia, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA. vlima@mcg.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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