Linked Life Data

20977796

Source:http://linkedlifedata.com/resource/pubmed/id/20977796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-27
pubmed:abstractText
Schizophrenia is a complex genetic disorder which is caused by multiple heritable and environmental factors. Large-scale screening of the entire DNA has recently resulted in the identification of several DNA variants associated with schizophrenia. The variants identified are single nucleotide polymorphisms (SNPs) with a high frequency in the population and a small effect, and rare copy number variants (CNVs) with larger effects. Variants are not unique to patients, and appear to be involved in multiple psychiatric disorders. The underlying biological mechanisms are not evident. Together, the identified variants only explain a fraction of all cases of the disease. Genetic testing of family members of patients may become feasible in the near future. For other clinical applications additional variants need to be identified first.
pubmed:language
dut
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1876-8784
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
A1909
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Genetic variation with increased risk of schizophrenia].
pubmed:affiliation
Universitair Medisch Centrum Utrecht, Afdeling Psychiatrie, Rudolf Magnus Instituut, Utrecht, the Netherlands. sbakker2@umcutrecht.nl
pubmed:publicationType
Journal Article, English Abstract, Review