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rdf:type |
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lifeskim:mentions |
umls-concept:C0018956,
umls-concept:C0023689,
umls-concept:C0041538,
umls-concept:C0042993,
umls-concept:C0162610,
umls-concept:C0599946,
umls-concept:C1414313,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1710082
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pubmed:dateCreated |
2010-11-12
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pubmed:abstractText |
Attenuation of the EGFR (Epidermal Growth Factor Receptor) signalling cascade is crucial to control cell fate during development. A candidate-based RNAi approach in C. elegans identified CDT-2 as an attenuator of LET-23 (EGFR) signalling. Human CDT2 is a component of the conserved CDT2/CUL4/DDB1 ubiquitin ligase complex that plays a critical role in DNA replication and G2/M checkpoint. Within this complex, CDT2 is responsible for substrate recognition. This ubiquitin ligase complex has been shown in various organisms, including C. elegans, to target the replication-licensing factor CDT1, and the CDK inhibitor p21. However, no previous link to EGFR signalling has been identified.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cdt-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Cul-4 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/let-23 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-213X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109
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pubmed:meshHeading |
pubmed-meshheading:20977703-Animals,
pubmed-meshheading:20977703-Animals, Genetically Modified,
pubmed-meshheading:20977703-Caenorhabditis elegans,
pubmed-meshheading:20977703-Caenorhabditis elegans Proteins,
pubmed-meshheading:20977703-Endocytosis,
pubmed-meshheading:20977703-Epistasis, Genetic,
pubmed-meshheading:20977703-Female,
pubmed-meshheading:20977703-Gene Deletion,
pubmed-meshheading:20977703-Humans,
pubmed-meshheading:20977703-Ligases,
pubmed-meshheading:20977703-RNA Interference,
pubmed-meshheading:20977703-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20977703-Receptors, Notch,
pubmed-meshheading:20977703-Recombinant Fusion Proteins,
pubmed-meshheading:20977703-Signal Transduction,
pubmed-meshheading:20977703-Stem Cells,
pubmed-meshheading:20977703-Ubiquitin-Protein Ligases,
pubmed-meshheading:20977703-Vulva
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pubmed:year |
2010
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pubmed:articleTitle |
The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.
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pubmed:affiliation |
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. Gino.Poulin@manchester.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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