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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-11-11
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pubmed:abstractText |
The steroid hormone testosterone has been found to be greatly reduced by opioids in different experimental and clinical conditions. The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis. Testosterone was determined in the plasma and in the brain, morphine was assayed in the plasma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
pubmed-author:AloisiAnna MariaAM,
pubmed-author:AnziniMaurizioM,
pubmed-author:CappelliAndreaA,
pubmed-author:CeccarelliIlariaI,
pubmed-author:DanielliBarbaraB,
pubmed-author:FiorenzaniPaoloP,
pubmed-author:GiordanoAntonioA,
pubmed-author:MaddalenaMelindaM,
pubmed-author:RossiAlessandraA,
pubmed-author:RoviniMicheleM,
pubmed-author:SordaGiuseppinaG,
pubmed-author:TomeiValentinaV
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69
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pubmed:meshHeading |
pubmed-meshheading:20977699-Animals,
pubmed-meshheading:20977699-Aromatase,
pubmed-meshheading:20977699-Behavior, Animal,
pubmed-meshheading:20977699-Brain,
pubmed-meshheading:20977699-Cholestenone 5 alpha-Reductase,
pubmed-meshheading:20977699-Formaldehyde,
pubmed-meshheading:20977699-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20977699-Male,
pubmed-meshheading:20977699-Morphine,
pubmed-meshheading:20977699-Organ Specificity,
pubmed-meshheading:20977699-Pain,
pubmed-meshheading:20977699-RNA, Messenger,
pubmed-meshheading:20977699-Rats,
pubmed-meshheading:20977699-Rats, Sprague-Dawley,
pubmed-meshheading:20977699-Testosterone
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pubmed:year |
2010
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pubmed:articleTitle |
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats.
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pubmed:affiliation |
Department of Physiology, Neuroscience and Applied Physiology Unit, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. aloisi@unisi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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