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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-26
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pubmed:abstractText |
Inflammation is commonly followed by the release of endogenous proteins called danger associated molecular patterns (DAMPs) that are able to warn the host for eminent danger. S100A8/A9 subunits are DAMPs that belong to the S100 family of calcium binding proteins. S100A8/A9 complexes induce an inflammatory response and their expression correlates with disease severity in several inflammatory disorders. S100A8/A9 promote endotoxin- and Escherichia (E.) coli-induced sepsis showing its contribution in systemic infection. The role of S100A8/A9 during a local infection of the urinary tract system caused by E. coli remains unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13394
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pubmed:meshHeading |
pubmed-meshheading:20976233-Animals,
pubmed-meshheading:20976233-Bacteria,
pubmed-meshheading:20976233-Calgranulin A,
pubmed-meshheading:20976233-Calgranulin B,
pubmed-meshheading:20976233-Colony Count, Microbial,
pubmed-meshheading:20976233-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20976233-Immunohistochemistry,
pubmed-meshheading:20976233-Inflammation Mediators,
pubmed-meshheading:20976233-Kidney,
pubmed-meshheading:20976233-Mice,
pubmed-meshheading:20976233-Mice, Inbred C57BL,
pubmed-meshheading:20976233-Mice, Knockout,
pubmed-meshheading:20976233-Urinary Bladder,
pubmed-meshheading:20976233-Urinary Tract Infections
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pubmed:year |
2010
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pubmed:articleTitle |
S100A8/A9 is not involved in host defense against murine urinary tract infection.
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pubmed:affiliation |
Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.c.dessing@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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