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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-26
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pubmed:abstractText |
The Trp(620) allotype of PTPN22 confers susceptibility to rheumatoid arthritis (RA) and certain other classical autoimmune diseases. There has been a report of other variants within the PTPN22 locus that alter risk of RA; protective haplotype '5', haplotype group '6-10' and susceptibility haplotype '4', suggesting the possibility of other PTPN22 variants involved in the pathogenesis of RA independent of R620W (rs2476601). Our aim was to further investigate this possibility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:DalbethNicolaN,
pubmed-author:GohPeter MPM,
pubmed-author:HarrisonAndrew AAA,
pubmed-author:HightonJohnJ,
pubmed-author:JonesPeter B BPB,
pubmed-author:MerrimanMarilyn EME,
pubmed-author:MerrimanTony RTR,
pubmed-author:SmythDeborah JDJ,
pubmed-author:StampLisaL,
pubmed-author:SteerSophiaS,
pubmed-author:ToddJohn AJA,
pubmed-author:Wan TaibWan RWR
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13544
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pubmed:meshHeading |
pubmed-meshheading:20975833-Arthritis, Rheumatoid,
pubmed-meshheading:20975833-Base Sequence,
pubmed-meshheading:20975833-Genetic Predisposition to Disease,
pubmed-meshheading:20975833-Haplotypes,
pubmed-meshheading:20975833-Humans,
pubmed-meshheading:20975833-Molecular Sequence Data,
pubmed-meshheading:20975833-Polymerase Chain Reaction,
pubmed-meshheading:20975833-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:20975833-Polymorphism, Single Nucleotide,
pubmed-meshheading:20975833-Protein Tyrosine Phosphatase, Non-Receptor Type 22,
pubmed-meshheading:20975833-Risk Factors
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pubmed:year |
2010
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pubmed:articleTitle |
The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.
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pubmed:affiliation |
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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