Linked Life Data

20975832

Source:http://linkedlifedata.com/resource/pubmed/id/20975832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-26
pubmed:abstractText
The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e13502
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.
pubmed:affiliation
YCR p53 Research Unit, Department of Biology, University of York, York, United Kingdom. clynch@cnio.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't