|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002932,
umls-concept:C0006142,
umls-concept:C0079189,
umls-concept:C0205225,
umls-concept:C0449851,
umls-concept:C0623362,
umls-concept:C0871261,
umls-concept:C0920424,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-10-26
|
|
pubmed:abstractText |
Breast cancer is the most common malignancy in women. Surgery remains the most effective treatment. Several perioperative factors, including the surgical stress response, many anesthetics and opioids, adversely affect immune function. Regional anesthesia-analgesia attenuates perioperative immunosuppression. We tested the hypothesis that patients who receive combined propofol/paravertebral anesthesia-analgesia (propofol/paravertebral) exhibited reduced levels of protumorigenic cytokines and matrix metalloproteinases (MMPs) and elevated levels of antitumorigenic cytokines compared with patients receiving sevoflurane anesthesia with opioid analgesia (sevoflurane/opioid).
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Intravenous,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Bupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/MMP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MMP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Propofol,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/levobupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1532-8651
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
490-5
|
|
pubmed:meshHeading |
pubmed-meshheading:20975461-Aged,
pubmed-meshheading:20975461-Analgesics, Opioid,
pubmed-meshheading:20975461-Anesthesia, Conduction,
pubmed-meshheading:20975461-Anesthetics, Inhalation,
pubmed-meshheading:20975461-Anesthetics, Intravenous,
pubmed-meshheading:20975461-Anesthetics, Local,
pubmed-meshheading:20975461-Breast Neoplasms,
pubmed-meshheading:20975461-Bupivacaine,
pubmed-meshheading:20975461-Cytokines,
pubmed-meshheading:20975461-Female,
pubmed-meshheading:20975461-Humans,
pubmed-meshheading:20975461-Immunity, Cellular,
pubmed-meshheading:20975461-Interferon-gamma,
pubmed-meshheading:20975461-Interleukins,
pubmed-meshheading:20975461-Ireland,
pubmed-meshheading:20975461-Mastectomy,
pubmed-meshheading:20975461-Matrix Metalloproteinase 1,
pubmed-meshheading:20975461-Matrix Metalloproteinase 3,
pubmed-meshheading:20975461-Matrix Metalloproteinase 9,
pubmed-meshheading:20975461-Matrix Metalloproteinases,
pubmed-meshheading:20975461-Methyl Ethers,
pubmed-meshheading:20975461-Middle Aged,
pubmed-meshheading:20975461-Morphine,
pubmed-meshheading:20975461-Nerve Block,
pubmed-meshheading:20975461-Pain, Postoperative,
pubmed-meshheading:20975461-Pilot Projects,
pubmed-meshheading:20975461-Propofol,
pubmed-meshheading:20975461-Time Factors,
pubmed-meshheading:20975461-Treatment Outcome,
pubmed-meshheading:20975461-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery.
|
|
pubmed:affiliation |
Department of Anesthesia and Intensive Care Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
