|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
2010-11-9
|
|
pubmed:abstractText |
Pulmonary hypertension (PH) is among the complications of HIV infection. Combination antiretroviral therapy may influence the progression of HIV-related PH. Because Akt signaling is a potential molecular target of HIV protease inhibitors (HPIs), we hypothesized that these drugs altered monocrotaline- and hypoxia-induced PH in rats by downregulating the Akt pathway, thereby inhibiting pulmonary artery smooth muscle cell proliferation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-10382692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-11602621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-12094235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-12114197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-12615632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-12690034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-12805073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-14522993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-15095226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-15168016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-15927991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-15931382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16166302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16195541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16200212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16551874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16782881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16844879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-16940204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-17133272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-17932378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-18845916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-18845923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-19218343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-19567610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-19770696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-8990341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20974998-9117037
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
pubmed-author:AdnotSergeS,
pubmed-author:AmsellemValerieV,
pubmed-author:BrégeonJérémyJ,
pubmed-author:Dubois-RandéJean-LucJL,
pubmed-author:Gary-BoboGuillaumeG,
pubmed-author:HoussainiAmalA,
pubmed-author:MarcosElisabethE,
pubmed-author:PacaudPierreP,
pubmed-author:PerrinAlineA,
pubmed-author:RideauDominiqueD,
pubmed-author:SavaleLaurentL,
pubmed-author:SitbonOlivierO
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
9
|
|
pubmed:volume |
122
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1937-47
|
|
pubmed:dateRevised |
2011-8-25
|
|
pubmed:meshHeading |
pubmed-meshheading:20974998-Animals,
pubmed-meshheading:20974998-Animals, Newborn,
pubmed-meshheading:20974998-Anoxia,
pubmed-meshheading:20974998-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:20974998-Antiviral Agents,
pubmed-meshheading:20974998-Blood Pressure,
pubmed-meshheading:20974998-Carbamates,
pubmed-meshheading:20974998-Cell Division,
pubmed-meshheading:20974998-HIV Protease Inhibitors,
pubmed-meshheading:20974998-Hemodynamics,
pubmed-meshheading:20974998-Hypertension, Pulmonary,
pubmed-meshheading:20974998-Male,
pubmed-meshheading:20974998-Monocrotaline,
pubmed-meshheading:20974998-Nelfinavir,
pubmed-meshheading:20974998-Pulmonary Artery,
pubmed-meshheading:20974998-Rats,
pubmed-meshheading:20974998-Rats, Wistar,
pubmed-meshheading:20974998-Ritonavir,
pubmed-meshheading:20974998-Sulfonamides
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.
|
|
pubmed:affiliation |
INSERM U955 and Département de Physiologie Hôpital Henri Mondor, Créteil, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
