Linked Life Data

20974120

Source:http://linkedlifedata.com/resource/pubmed/id/20974120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-10
pubmed:abstractText
Morphogenesis is a fascinating but complex and incompletely understood developmental process. The sensory lateral line system consists of only a few hundred cells and is experimentally accessible making it an excellent model system to interrogate the cellular and molecular mechanisms underlying segmental morphogenesis. The posterior lateral line primordium periodically deposits prosensory organs as it migrates to the tail tip. We demonstrate that periodic proneuromast deposition is governed by a fundamentally different developmental mechanism than the classical models of developmental periodicity represented by vertebrate somitogenesis and early Drosophila development. Our analysis demonstrates that proneuromast deposition is driven by periodic lengthening of the primordium and a stable Wnt/?-catenin activation domain in the leading region of the primordium. The periodic lengthening of the primordium is controlled by Wnt/?-catenin/Fgf-dependent proliferation. Once proneuromasts are displaced into the trailing Wnt/?-catenin-free zone they are deposited. We have previously shown that Wnt/?-catenin signaling induces Fgf signaling and that interactions between these two pathways regulate primordium migration and prosensory organ formation. Therefore, by coordinating migration, prosensory organ formation and proliferation, localized activation of Wnt/?-catenin signaling in the leading zone of the primordium plays a crucial role in orchestrating lateral line morphogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1095-564X
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
349
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
470-82
pubmed:meshHeading
pubmed-meshheading:20974120-Animals, pubmed-meshheading:20974120-Aphidicolin, pubmed-meshheading:20974120-Bromodeoxyuridine, pubmed-meshheading:20974120-Cell Proliferation, pubmed-meshheading:20974120-DNA Primers, pubmed-meshheading:20974120-Embryo, Nonmammalian, pubmed-meshheading:20974120-Fibroblast Growth Factors, pubmed-meshheading:20974120-Gene Knockout Techniques, pubmed-meshheading:20974120-Hydroxyurea, pubmed-meshheading:20974120-In Situ Hybridization, pubmed-meshheading:20974120-In Situ Nick-End Labeling, pubmed-meshheading:20974120-Lateral Line System, pubmed-meshheading:20974120-Morphogenesis, pubmed-meshheading:20974120-Pyrroles, pubmed-meshheading:20974120-Signal Transduction, pubmed-meshheading:20974120-Time-Lapse Imaging, pubmed-meshheading:20974120-Transcription Factors, pubmed-meshheading:20974120-Wnt Proteins, pubmed-meshheading:20974120-Zebrafish, pubmed-meshheading:20974120-beta Catenin
pubmed:year
2011
pubmed:articleTitle
Wnt/?-catenin dependent cell proliferation underlies segmented lateral line morphogenesis.
pubmed:affiliation
University of Utah Medical School, Dept. of Neurobiology and Anatomy, MREB 401, Salt Lake City, UT 84132, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural