Linked Life Data

2097334

Source:http://linkedlifedata.com/resource/pubmed/id/2097334

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-7-25
pubmed:abstractText
The circumstances which cause the ripening of the cervix during the initial phase of parturition are still unexplored. In addition, complications during labour such as cervical dystocia still necessitate cesarian section. Therefore we examined the biomechanical alterations of the cervix during the last trimester of pregnancy. We developed a special method to measure dilatation and resistance of the rat cervix. After testing several substances, the antigestagen Mifepristone turned out to be most effective in causing cervical softening. Further investigations with light and scanning electron microscopy showed an increase of collagen and a possible loosening of collagen fibers after antigestagen treatment. Therefore it might be possible to use Mifepristone, perhaps in combination with a prostaglandin to promote cervical ripening when certain obstetric problems arise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5577
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-29
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cervical ripening of the rat in dependence on endocrine milieu; effects of antigestagens.
pubmed:affiliation
Department of Obstetrics and Gynecology, Free University of Berlin, Germany.
pubmed:publicationType
Journal Article