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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-10
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pubmed:abstractText |
Intracoronary injection of bone marrow mononuclear cells (BMMNC) is a common clinical protocol of cell transplantation for heart disease, but poor engraftment of donor cells in the heart, which will limit its therapeutic efficacy, is a major issue. Initial "retention" (endothelial adherence and/or extravasation) of BMMNC immediately after intracoronary injection is a key step toward successful engraftment; however, this event has not been fully characterized. The aim of this study is to quantitatively clarify the frequency of "retention" of BMMNC after intracoronary injection, determine the impact of prior induction of ischemia-reperfusion injury on "retention" efficiency, and elucidate the underlying mechanisms focusing on adhesion molecule-mediated cell-cell interactions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Ly6a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P-selectin ligand protein,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1557-3117
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-33
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pubmed:meshHeading |
pubmed-meshheading:20971657-Animals,
pubmed-meshheading:20971657-Antigens, CD18,
pubmed-meshheading:20971657-Antigens, Ly,
pubmed-meshheading:20971657-Bone Marrow Cells,
pubmed-meshheading:20971657-Bone Marrow Transplantation,
pubmed-meshheading:20971657-Cell Communication,
pubmed-meshheading:20971657-Coronary Vessels,
pubmed-meshheading:20971657-Endothelium, Vascular,
pubmed-meshheading:20971657-Green Fluorescent Proteins,
pubmed-meshheading:20971657-Intercellular Adhesion Molecule-1,
pubmed-meshheading:20971657-Membrane Glycoproteins,
pubmed-meshheading:20971657-Membrane Proteins,
pubmed-meshheading:20971657-Mice,
pubmed-meshheading:20971657-Mice, Inbred C57BL,
pubmed-meshheading:20971657-Mice, Transgenic,
pubmed-meshheading:20971657-Models, Animal,
pubmed-meshheading:20971657-Myocardial Reperfusion Injury,
pubmed-meshheading:20971657-P-Selectin,
pubmed-meshheading:20971657-Regional Blood Flow,
pubmed-meshheading:20971657-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2011
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pubmed:articleTitle |
Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries.
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pubmed:affiliation |
Harefield Heart Science Centre, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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