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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
We have previously shown that CLA induces regression of pre-established atherosclerotic lesions in apoE(-/-) mice. CLA is a known ligand of peroxisome proliferator activated receptors (PPARs) and it is postulated that CLA mediates its atheroprotective effects through activation of PPARs. Earlier work in our group identified the monocyte/macrophage cell as the primary cellular target of CLA. In this study we identified novel genes regulated by CLA during the regression of atherosclerosis and characterised a role for one of these, SorLA. SorLA is a member of the vacuolar protein sorting 10 protein (Vps10p) domain receptor family, which has structural homology with the LDLR family.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9,11-linoleic acid,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids, Conjugated,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Urokinase Plasminogen...,
http://linkedlifedata.com/resource/pubmed/chemical/Sorl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/troglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
213
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
400-7
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pubmed:dateRevised |
2011-6-22
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pubmed:meshHeading |
pubmed-meshheading:20970138-Animals,
pubmed-meshheading:20970138-Atherosclerosis,
pubmed-meshheading:20970138-Cell Movement,
pubmed-meshheading:20970138-Chemokine CCL2,
pubmed-meshheading:20970138-Chromans,
pubmed-meshheading:20970138-Humans,
pubmed-meshheading:20970138-Linoleic Acids, Conjugated,
pubmed-meshheading:20970138-Membrane Transport Proteins,
pubmed-meshheading:20970138-Mice,
pubmed-meshheading:20970138-Monocytes,
pubmed-meshheading:20970138-PPAR gamma,
pubmed-meshheading:20970138-Receptors, LDL,
pubmed-meshheading:20970138-Receptors, Urokinase Plasminogen Activator,
pubmed-meshheading:20970138-Thiazolidinediones
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pubmed:year |
2010
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pubmed:articleTitle |
SorLA modulates atheroprotective properties of CLA by regulating monocyte migration.
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pubmed:affiliation |
School of Biomedical and Biomolecular Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. c.mccarthy@ucd.ie
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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