Linked Life Data

20969894

Source:http://linkedlifedata.com/resource/pubmed/id/20969894

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Interferons lambda (IFN-?) are the most recently defined members of the class III cytokine family. To investigate whether IFN-?2 and IFN-?3 displayed antiviral activity against influenza A virus (IAV), a number of cell lines induced with IFNs - as well as two established cell lines (A549-IFN-?2 and A549-IFN-?3) - were infected with IAV. Our results indicate that IFN-?2 has statistically significant antiviral activity in A549-IFN-?2 (P=0.0028) although less so than IFN-?3, which reduced viral titer to 10% (P<0.0001). The reverse was observed for cells treated with IFNs, with IFN-?2-treated A549 cells inhibiting IAV infection more efficiently than IFN-?3-treated A549 cells. The antiviral effect on IFN-stimulated cells was most apparent on Vero cells (compared with MDCK and HeLa). Both IFNs significantly inhibited IAV replication and inhibition was observed in a dose-dependent manner, with an optimal IFN concentration of 20 ng/ml. IFN-?2 was more potent than IFN-?3 on Vero cells while IFN-?3 appeared more efficient than IFN-?2 on MDCK and HeLa cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-9096
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-33
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Influenza A virus replication is inhibited in IFN-?2 and IFN-?3 transfected or stimulated cells.
pubmed:affiliation
Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't