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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
activity of the large conductance Ca(2+)-activated K(+) (BK) channels is profoundly modulated by its ?(1) subunit (BK-?(1)). However, BK-?(1) expression is downregulated in diabetic vessels. The ubiquitin-proteasome system (UPS) is a major mechanism of intracellular protein degradation. Whether UPS participates in BK-?(1) downregulation in diabetic vessels is unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1454-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20966391-Cells, Cultured,
pubmed-meshheading:20966391-Diabetes Mellitus,
pubmed-meshheading:20966391-Down-Regulation,
pubmed-meshheading:20966391-F-Box Proteins,
pubmed-meshheading:20966391-Forkhead Transcription Factors,
pubmed-meshheading:20966391-Glucose,
pubmed-meshheading:20966391-Humans,
pubmed-meshheading:20966391-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:20966391-Muscle, Smooth, Vascular,
pubmed-meshheading:20966391-Myocytes, Smooth Muscle,
pubmed-meshheading:20966391-Proteasome Endopeptidase Complex,
pubmed-meshheading:20966391-Protein Stability,
pubmed-meshheading:20966391-Protein Subunits,
pubmed-meshheading:20966391-Ubiquitin
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pubmed:year |
2010
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pubmed:articleTitle |
Muscle-specific f-box only proteins facilitate bk channel ?(1) subunit downregulation in vascular smooth muscle cells of diabetes mellitus.
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pubmed:affiliation |
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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