Source:http://linkedlifedata.com/resource/pubmed/id/20966166
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2011-2-4
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| pubmed:abstractText |
Intestinal T-cell and natural killer (NK)-cell lymphomas are clinically aggressive and can be challenging to diagnose in small endoscopic biopsies. We describe 8 patients in whom atypical NK-cell lymphoproliferative lesions mimicked NK- or T-cell lymphoma. The patients (2 men; 6 women; ages 27-68 years) presented with vague gastrointestinal symptoms with lesions involving stomach, duodenum, small intestine, and colon. At endoscopy, the lesions exhibited superficial ulceration, edema, and hemorrhage. Biopsies revealed a mucosal infiltrate of atypical cells with an NK-cell phenotype (CD56(+)/TIA-1(+)/Granzyme B(+)/cCD3(+)), which displaced but did not invade the glandular epithelium. Epstein-Barr virus-encoded RNA in situ hybridization was negative, and T-cell receptor-? gene rearrangement showed no evidence of a clonal process. Based on an original diagnosis of lymphoma, 3 patients received aggressive chemotherapy followed by autologous bone marrow transplantation in 2. Five patients were followed without treatment. However, no patient developed progressive disease or died of lymphoma (median follow-up, 30 months). Repeat endoscopies in 6 of 8 patients showed persistence or recurrence of superficial gastrointestinal lesions. This unique entity mimics intestinal and NK-/T-cell lymphomas on endoscopic biopsies and can result in erroneous diagnosis, leading to aggressive chemotherapy. We propose the term "NK-cell enteropathy" for this syndrome of as yet unknown etiology.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
1528-0020
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
3
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| pubmed:volume |
117
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1447-52
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| pubmed:meshHeading |
pubmed-meshheading:20966166-Adult,
pubmed-meshheading:20966166-Aged,
pubmed-meshheading:20966166-Antineoplastic Agents,
pubmed-meshheading:20966166-Bone Marrow Transplantation,
pubmed-meshheading:20966166-Diagnosis, Differential,
pubmed-meshheading:20966166-Endoscopy, Gastrointestinal,
pubmed-meshheading:20966166-Female,
pubmed-meshheading:20966166-Follow-Up Studies,
pubmed-meshheading:20966166-Humans,
pubmed-meshheading:20966166-Immunoenzyme Techniques,
pubmed-meshheading:20966166-Immunophenotyping,
pubmed-meshheading:20966166-Intestinal Neoplasms,
pubmed-meshheading:20966166-Killer Cells, Natural,
pubmed-meshheading:20966166-Lymphoma, T-Cell,
pubmed-meshheading:20966166-Lymphoproliferative Disorders,
pubmed-meshheading:20966166-Male,
pubmed-meshheading:20966166-Middle Aged,
pubmed-meshheading:20966166-Prognosis
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series.
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| pubmed:affiliation |
Department of Pathology & Laboratory Medicine/Calgary Laboratory Services, Calgary, Alberta, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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