| pubmed-article:20962770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0521362 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C1425008 | lld:lifeskim |
| pubmed-article:20962770 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20962770 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20962770 | pubmed:dateCreated | 2011-4-19 | lld:pubmed |
| pubmed-article:20962770 | pubmed:abstractText | Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. In this study we show that Ndfip1-/- mice also develop inflammation in the gastrointestinal tract. Inflammation is characterized by infiltration of eosinophils and T cells and is accompanied by a failure to gain weight. T cells are both necessary and sufficient for eosinophil recruitment and inflammation. This is because Ndfip1-/- T cells become activated and produce IL-5. Itch mutant mice develop much less severe gastrointestinal inflammation, suggesting that Ndfip1 regulation of Itch cannot entirely account for this phenotype and that Ndfip1 has both Itch-dependent and Itch-independent roles. Ndfip1 may also regulate human disease. We found single-nucleotide polymorphisms in the Ndfip1 locus that associate with inflammatory bowel disease. Taken together, our data support a role for Ndfip1 in gastrointestinal inflammation in both mice and humans. | lld:pubmed |
| pubmed-article:20962770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20962770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20962770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20962770 | pubmed:month | May | lld:pubmed |
| pubmed-article:20962770 | pubmed:issn | 1935-3456 | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:YanoJJ | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:BradfieldJJ | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:OliverP MPM | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:HakonarsonHH | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:RamonH EHE | lld:pubmed |
| pubmed-article:20962770 | pubmed:author | pubmed-author:RilingC RCR | lld:pubmed |
| pubmed-article:20962770 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20962770 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:20962770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20962770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20962770 | pubmed:pagination | 314-24 | lld:pubmed |
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| pubmed-article:20962770 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20962770 | pubmed:articleTitle | The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility. | lld:pubmed |
| pubmed-article:20962770 | pubmed:affiliation | University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. | lld:pubmed |
| pubmed-article:20962770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20962770 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:65113 | entrezgene:pubmed | pubmed-article:20962770 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20962770 | lld:entrezgene |
