Source:http://linkedlifedata.com/resource/pubmed/id/20962770
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-4-19
|
| pubmed:abstractText |
Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. In this study we show that Ndfip1-/- mice also develop inflammation in the gastrointestinal tract. Inflammation is characterized by infiltration of eosinophils and T cells and is accompanied by a failure to gain weight. T cells are both necessary and sufficient for eosinophil recruitment and inflammation. This is because Ndfip1-/- T cells become activated and produce IL-5. Itch mutant mice develop much less severe gastrointestinal inflammation, suggesting that Ndfip1 regulation of Itch cannot entirely account for this phenotype and that Ndfip1 has both Itch-dependent and Itch-independent roles. Ndfip1 may also regulate human disease. We found single-nucleotide polymorphisms in the Ndfip1 locus that associate with inflammatory bowel disease. Taken together, our data support a role for Ndfip1 in gastrointestinal inflammation in both mice and humans.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Itch protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ndfip1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1935-3456
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
314-24
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| pubmed:meshHeading |
pubmed-meshheading:20962770-Animals,
pubmed-meshheading:20962770-Carrier Proteins,
pubmed-meshheading:20962770-Cell Movement,
pubmed-meshheading:20962770-Cells, Cultured,
pubmed-meshheading:20962770-Eosinophils,
pubmed-meshheading:20962770-Genetic Predisposition to Disease,
pubmed-meshheading:20962770-Inflammation,
pubmed-meshheading:20962770-Inflammatory Bowel Diseases,
pubmed-meshheading:20962770-Interleukin-5,
pubmed-meshheading:20962770-Intestines,
pubmed-meshheading:20962770-Membrane Proteins,
pubmed-meshheading:20962770-Mice,
pubmed-meshheading:20962770-Mice, Inbred C57BL,
pubmed-meshheading:20962770-Mice, Knockout,
pubmed-meshheading:20962770-Mice, Mutant Strains,
pubmed-meshheading:20962770-Polymorphism, Single Nucleotide,
pubmed-meshheading:20962770-T-Lymphocytes,
pubmed-meshheading:20962770-Th1-Th2 Balance,
pubmed-meshheading:20962770-Ubiquitin-Protein Ligases
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.
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| pubmed:affiliation |
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|