Linked Life Data

20962766

Source:http://linkedlifedata.com/resource/pubmed/id/20962766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-1-13
pubmed:abstractText
The purpose of this study was to determine whether meeting historical criteria for unsuspected Wernicke's encephalopathy (WE), largely under-diagnosed in vivo, explains why some alcoholics have severe neuropsychological deficits, whereas others, with a similar drinking history, exhibit preserved performance. Demographic, clinical, alcohol related, and neuropsychological measures were collected in 56 abstinent alcoholics and 38 non-alcohol-dependent volunteers. Alcoholics were classified using the clinical criteria established by Caine et al (1997) and validated in their neuropathological study of alcoholic cases. Our alcoholics who met a single criterion were considered 'at risk for WE' and those with two or more criteria with 'signs of WE'. Whole blood thiamine was also measured in 22 of the comparison group and 28 alcoholics. Of the alcoholics examined, 27% met no criteria, 57% were at risk for WE, and 16% had signs of WE. Neuropsychological performance of the alcoholic subgroups was graded, with those meeting zero criteria not differing from controls, those meeting one criterion presenting mild-to-moderate deficits on some of the functional domains, and those meeting two or more criteria having the most severe deficits on each of the domains examined. Thiamine levels were selectively related to memory performance in the alcoholics. Preclinical signs of WE can be diagnosed in vivo, enabling the identification of ostensibly 'uncomplicated' alcoholics who are at risk for neuropsychological complications. The graded effects in neuropsychological performance suggest that the presence of signs of WE explains, at least partially, the heterogeneity of alcoholism-related cognitive and motor deficits.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1740-634X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
580-8
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed-meshheading:20962766-Adult, pubmed-meshheading:20962766-Alcohol Amnestic Disorder, pubmed-meshheading:20962766-Alcoholism, pubmed-meshheading:20962766-Analysis of Variance, pubmed-meshheading:20962766-Cognition Disorders, pubmed-meshheading:20962766-Female, pubmed-meshheading:20962766-Follow-Up Studies, pubmed-meshheading:20962766-Humans, pubmed-meshheading:20962766-Intelligence, pubmed-meshheading:20962766-Male, pubmed-meshheading:20962766-Memory, pubmed-meshheading:20962766-Middle Aged, pubmed-meshheading:20962766-Neuropsychological Tests, pubmed-meshheading:20962766-Predictive Value of Tests, pubmed-meshheading:20962766-Regression Analysis, pubmed-meshheading:20962766-Severity of Illness Index, pubmed-meshheading:20962766-Thiamine, pubmed-meshheading:20962766-Wernicke Encephalopathy
pubmed:year
2011
pubmed:articleTitle
Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5723, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural