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rdf:type |
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lifeskim:mentions |
umls-concept:C0031268,
umls-concept:C0032743,
umls-concept:C0035647,
umls-concept:C0040399,
umls-concept:C0205314,
umls-concept:C0206754,
umls-concept:C0243071,
umls-concept:C0456387,
umls-concept:C0597354,
umls-concept:C0679622,
umls-concept:C1527121
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)-positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet. Hypothesizing that the introduction of conformational constraints may lead to receptor subtype selectivity or may help to delineate structural features determining pansomatostatin potency, we developed and evaluated first examples of this new class of potential radiotracers for imaging or therapy of neuroendocrine tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4,7,10-tetraazacyclododecane-...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Gallium Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds, 1-Ring,
http://linkedlifedata.com/resource/pubmed/chemical/Lutetium,
http://linkedlifedata.com/resource/pubmed/chemical/Radioactive Tracers,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1535-5667
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1771-9
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pubmed:meshHeading |
pubmed-meshheading:20956465-Animals,
pubmed-meshheading:20956465-CHO Cells,
pubmed-meshheading:20956465-Calcium,
pubmed-meshheading:20956465-Cell Transformation, Neoplastic,
pubmed-meshheading:20956465-Cricetinae,
pubmed-meshheading:20956465-Cricetulus,
pubmed-meshheading:20956465-Drug Design,
pubmed-meshheading:20956465-Enzyme Stability,
pubmed-meshheading:20956465-Female,
pubmed-meshheading:20956465-Gallium Radioisotopes,
pubmed-meshheading:20956465-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20956465-HEK293 Cells,
pubmed-meshheading:20956465-Heterocyclic Compounds, 1-Ring,
pubmed-meshheading:20956465-Humans,
pubmed-meshheading:20956465-Lutetium,
pubmed-meshheading:20956465-Mice,
pubmed-meshheading:20956465-Neuroendocrine Tumors,
pubmed-meshheading:20956465-Positron-Emission Tomography,
pubmed-meshheading:20956465-Protein Transport,
pubmed-meshheading:20956465-Radioactive Tracers,
pubmed-meshheading:20956465-Receptors, Somatostatin,
pubmed-meshheading:20956465-Somatostatin,
pubmed-meshheading:20956465-Structure-Activity Relationship,
pubmed-meshheading:20956465-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2010
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pubmed:articleTitle |
Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors.
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pubmed:affiliation |
Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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