Source:http://linkedlifedata.com/resource/pubmed/id/20955815
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2011-1-3
|
pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1769-714X
|
pubmed:author |
pubmed-author:AdachiAkioA,
pubmed-author:AkariHirofumiH,
pubmed-author:HayakawaToshiyukiT,
pubmed-author:IijimaSayukiS,
pubmed-author:KonoKenK,
pubmed-author:KuroishiAyumuA,
pubmed-author:LeeYoung-JungYJ,
pubmed-author:MatanoTetsuroT,
pubmed-author:NakayamaEmi EEE,
pubmed-author:NomaguchiMasakoM,
pubmed-author:SaitoAkatsukiA,
pubmed-author:ShiodaTatsuoT,
pubmed-author:YasutomiYasuhiroY,
pubmed-author:YoshidaTomoyukiT
|
pubmed:copyrightInfo |
Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
58-64
|
pubmed:meshHeading |
pubmed-meshheading:20955815-Animals,
pubmed-meshheading:20955815-HIV Infections,
pubmed-meshheading:20955815-HIV-1,
pubmed-meshheading:20955815-Host Specificity,
pubmed-meshheading:20955815-Humans,
pubmed-meshheading:20955815-Lymphocyte Depletion,
pubmed-meshheading:20955815-Macaca fascicularis,
pubmed-meshheading:20955815-Simian immunodeficiency virus,
pubmed-meshheading:20955815-Viremia,
pubmed-meshheading:20955815-Virus Replication
|
pubmed:year |
2011
|
pubmed:articleTitle |
Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications.
|
pubmed:affiliation |
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|