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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-10-29
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pubmed:abstractText |
The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
pubmed-author:AmianoPilarP,
pubmed-author:ArdanazEvaE,
pubmed-author:BoeingHeinerH,
pubmed-author:Bueno-de-MesquitaH BasHB,
pubmed-author:CampaDanieleD,
pubmed-author:CanzianFedericoF,
pubmed-author:Chabbert-BuffetNathalieN,
pubmed-author:ChajesVeroniqueV,
pubmed-author:ChirlaqueMaría DoloresMD,
pubmed-author:Clavel-ChapelonFrançoiseF,
pubmed-author:FagherazziGuyG,
pubmed-author:FisherEvaE,
pubmed-author:HüsingAnikaA,
pubmed-author:HallmansGöranG,
pubmed-author:KaaksRudolfR,
pubmed-author:KeyTimothy JTJ,
pubmed-author:KhawKay-TeeKT,
pubmed-author:KroghVittorioV,
pubmed-author:LennerPerP,
pubmed-author:LundEilivE,
pubmed-author:MasalaGiovannaG,
pubmed-author:McKayJames DJD,
pubmed-author:Molina-MontesEstherE,
pubmed-author:Onland-MoretN CharlotteNC,
pubmed-author:OustoglouErifiliE,
pubmed-author:OvervadKimK,
pubmed-author:PanicoSalvatoreS,
pubmed-author:QuirósJosé RamonJR,
pubmed-author:RiboliElioE,
pubmed-author:RinaldiSabinaS,
pubmed-author:RohrmannSabineS,
pubmed-author:SacerdoteCarlottaC,
pubmed-author:SalaNúriaN,
pubmed-author:SiddiqAfshanA,
pubmed-author:SinilnikovaOlgaO,
pubmed-author:SlimaniNadiaN,
pubmed-author:SteggerJakobJ,
pubmed-author:TeucherBirgitB,
pubmed-author:TjønnelandAnneA,
pubmed-author:TravisRuth CRC,
pubmed-author:TrichopoulouAntoniaA,
pubmed-author:TuminoRosarioR,
pubmed-author:VogelUllaU,
pubmed-author:WarehamNickN,
pubmed-author:ZylisDimosthenisD,
pubmed-author:van GilsCarla HCH
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
563
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pubmed:meshHeading |
pubmed-meshheading:20955599-Adipose Tissue,
pubmed-meshheading:20955599-Adult,
pubmed-meshheading:20955599-Aged,
pubmed-meshheading:20955599-Body Mass Index,
pubmed-meshheading:20955599-Breast Neoplasms,
pubmed-meshheading:20955599-Case-Control Studies,
pubmed-meshheading:20955599-Cohort Studies,
pubmed-meshheading:20955599-Female,
pubmed-meshheading:20955599-Genome-Wide Association Study,
pubmed-meshheading:20955599-Genotype,
pubmed-meshheading:20955599-Humans,
pubmed-meshheading:20955599-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20955599-Membrane Proteins,
pubmed-meshheading:20955599-Middle Aged,
pubmed-meshheading:20955599-Models, Genetic,
pubmed-meshheading:20955599-Neoplasm Invasiveness,
pubmed-meshheading:20955599-Polymorphism, Genetic,
pubmed-meshheading:20955599-Risk
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pubmed:year |
2010
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pubmed:articleTitle |
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.
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pubmed:affiliation |
German Cancer Research Center (DKFZ), Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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