|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2010-11-15
|
|
pubmed:abstractText |
Inflammation of adipose tissue (AT) has been recently accepted as a first step towards obesity-mediated insulin resistance. We could previously show that mice fed with high fat diet (HFD) develop systemic insulin resistance (IR) and glucose intolerance (GI) associated with CD4-positive T-lymphocyte infiltration into visceral AT. These T-lymphocytes, when enriched in AT, participate in the development of fat tissue inflammation and subsequent recruitment of proinflammatory macrophages. The aim of this work was to elucidate the action of the insulin sensitizing PPARgamma on T-lymphocyte infiltration during development of IR, and comparison of the PPARgamma-mediated anti-inflammatory effects of rosiglitazone and telmisartan in diet-induced obesity model (DIO-model) in mice.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/CD3 antigen, gamma chain,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl12 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte-macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/rosiglitazone,
http://linkedlifedata.com/resource/pubmed/chemical/telmisartan
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1475-2840
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
64
|
|
pubmed:meshHeading |
pubmed-meshheading:20955583-Abdominal Fat,
pubmed-meshheading:20955583-Animals,
pubmed-meshheading:20955583-Anti-Inflammatory Agents,
pubmed-meshheading:20955583-Antigens, CD3,
pubmed-meshheading:20955583-Antigens, Differentiation,
pubmed-meshheading:20955583-Benzimidazoles,
pubmed-meshheading:20955583-Benzoates,
pubmed-meshheading:20955583-Chemokine CXCL12,
pubmed-meshheading:20955583-Chemotaxis,
pubmed-meshheading:20955583-Dietary Fats,
pubmed-meshheading:20955583-Disease Models, Animal,
pubmed-meshheading:20955583-Inflammation,
pubmed-meshheading:20955583-Insulin Resistance,
pubmed-meshheading:20955583-Lymphocyte Activation,
pubmed-meshheading:20955583-Macrophages,
pubmed-meshheading:20955583-Male,
pubmed-meshheading:20955583-Mice,
pubmed-meshheading:20955583-Mice, Inbred C57BL,
pubmed-meshheading:20955583-Obesity,
pubmed-meshheading:20955583-PPAR gamma,
pubmed-meshheading:20955583-T-Lymphocytes,
pubmed-meshheading:20955583-Thiazolidinediones,
pubmed-meshheading:20955583-Time Factors
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice.
|
|
pubmed:affiliation |
Center for Cardiovascular Research, Institute of Pharmacology Charité-Universitätsmedizin Berlin, Germany.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
