Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-10-18
pubmed:abstractText
Previous studies have shown anti-inflammatory potential of alkaline extract of the leaves of Sasa senanensis Rehder (SE). The aim of the present study was to clarity the molecular entity of SE, using various fractionation methods. SE inhibited the production of nitric oxide (NO), but not tumour necrosis factor-? by lipopolysaccharide (LPS)-stimulated mouse macrophage-like cells. Lignin carbohydrate complex prepared from SE inhibited the NO production to a comparable extent with SE, whereas chlorophyllin was more active. On successive extraction with organic solvents, nearly 90% of SE components, including chlorophyllin, were recovered from the aqueous layer. Anti-HIV activity of SE was comparable with that of lignin-carbohydrate complex, and much higher than that of chlorophyllin and n-butanol extract fractions. The CYP3A inhibitory activity of SE was significantly lower than that of grapefruit juice and chlorophyllin. Oral administration of SE slightly reduced the number of oral bacteria. When SE was applied to HPLC, nearly 70% of SE components were eluted as a single peak. These data suggest that multiple components of SE may be associated with each other in the native state or after extraction with alkaline solution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1791-7549
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-43
pubmed:meshHeading
pubmed-meshheading:20952742-Alkalies, pubmed-meshheading:20952742-Animals, pubmed-meshheading:20952742-Anti-Inflammatory Agents, pubmed-meshheading:20952742-Bacteroidaceae Infections, pubmed-meshheading:20952742-Cell Line, pubmed-meshheading:20952742-Chlorophyllides, pubmed-meshheading:20952742-Citrus paradisi, pubmed-meshheading:20952742-HIV Infections, pubmed-meshheading:20952742-Humans, pubmed-meshheading:20952742-Lignin, pubmed-meshheading:20952742-Lipopolysaccharides, pubmed-meshheading:20952742-Macrophages, pubmed-meshheading:20952742-Male, pubmed-meshheading:20952742-Mice, pubmed-meshheading:20952742-Microsomes, Liver, pubmed-meshheading:20952742-Nitric Oxide, pubmed-meshheading:20952742-Plant Extracts, pubmed-meshheading:20952742-Porphyromonas gingivalis, pubmed-meshheading:20952742-Rats, pubmed-meshheading:20952742-Sasa, pubmed-meshheading:20952742-Stomatitis, pubmed-meshheading:20952742-Tumor Necrosis Factor-alpha
pubmed:articleTitle
Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.
pubmed:affiliation
Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan. sakagami@dent.meikai.ac.jp
pubmed:publicationType
Journal Article, Clinical Trial