| pubmed-article:20952536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20952536 | lifeskim:mentions | umls-concept:C1159929 | lld:lifeskim |
| pubmed-article:20952536 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:20952536 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:20952536 | pubmed:dateCreated | 2010-10-18 | lld:pubmed |
| pubmed-article:20952536 | pubmed:abstractText | Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of biological processes. The magnitude and duration of cAMP expression are regulated by both production and hydrolysis. Melanocyte-stimulating hormone (MSH) plays a crucial role in pigment cell differentiation via cAMP-regulated expression of the master transcription factor MITF. We report the identification of phosphodiesterase 4D3 as a direct target of the MSH/cAMP/MITF pathway. This creates a negative feedback loop that induces refractoriness to chronic stimulation of the cAMP pathway in melanocytes. This homeostatic pathway highlights a potent mechanism controlling melanocyte differentiation that may be amenable to pharmacologic manipulation for skin cancer prevention. | lld:pubmed |
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| pubmed-article:20952536 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20952536 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20952536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20952536 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20952536 | pubmed:issn | 1549-5477 | lld:pubmed |
| pubmed-article:20952536 | pubmed:author | pubmed-author:FisherDavid... | lld:pubmed |
| pubmed-article:20952536 | pubmed:author | pubmed-author:LevyCarmitC | lld:pubmed |
| pubmed-article:20952536 | pubmed:author | pubmed-author:KhaledMehdiM | lld:pubmed |
| pubmed-article:20952536 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20952536 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20952536 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:20952536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20952536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20952536 | pubmed:pagination | 2276-81 | lld:pubmed |
| pubmed-article:20952536 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:20952536 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20952536 | pubmed:articleTitle | Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. | lld:pubmed |
| pubmed-article:20952536 | pubmed:affiliation | Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02114, USA. | lld:pubmed |
| pubmed-article:20952536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20952536 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:20952536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20952536 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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