20952536

Source:http://linkedlifedata.com/resource/pubmed/id/20952536

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C1159929, umls-concept:C2587213
pubmed:issue	20
pubmed:dateCreated	2010-10-18
pubmed:abstractText	Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of biological processes. The magnitude and duration of cAMP expression are regulated by both production and hydrolysis. Melanocyte-stimulating hormone (MSH) plays a crucial role in pigment cell differentiation via cAMP-regulated expression of the master transcription factor MITF. We report the identification of phosphodiesterase 4D3 as a direct target of the MSH/cAMP/MITF pathway. This creates a negative feedback loop that induces refractoriness to chronic stimulation of the cAMP pathway in melanocytes. This homeostatic pathway highlights a potent mechanism controlling melanocyte differentiation that may be amenable to pharmacologic manipulation for skin cancer prevention.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1AR058469, http://linkedlifedata.com/resource/pubmed/grant/AR043369-15, http://linkedlifedata.com/resource/pubmed/grant/R01 AR043369-16
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8711660
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Forskolin, http://linkedlifedata.com/resource/pubmed/chemical/Melanins, http://linkedlifedata.com/resource/pubmed/chemical/Melanocyte-Stimulating Hormones, http://linkedlifedata.com/resource/pubmed/chemical/Microphthalmia-Associated..., http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 4 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Rolipram
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1549-5477
pubmed:author	pubmed-author:FisherDavid EDE, pubmed-author:KhaledMehdiM, pubmed-author:LevyCarmitC
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2276-81
pubmed:dateRevised	2011-7-28
pubmed:meshHeading	pubmed-meshheading:20952536-Animals, pubmed-meshheading:20952536-Cell Differentiation, pubmed-meshheading:20952536-Cell Line, Tumor, pubmed-meshheading:20952536-Cells, Cultured, pubmed-meshheading:20952536-Cyclic AMP, pubmed-meshheading:20952536-Cyclic Nucleotide Phosphodiesterases, Type 4, pubmed-meshheading:20952536-Feedback, Physiological, pubmed-meshheading:20952536-Forskolin, pubmed-meshheading:20952536-Homeostasis, pubmed-meshheading:20952536-Humans, pubmed-meshheading:20952536-Immunoblotting, pubmed-meshheading:20952536-Infant, Newborn, pubmed-meshheading:20952536-Male, pubmed-meshheading:20952536-Melanins, pubmed-meshheading:20952536-Melanocyte-Stimulating Hormones, pubmed-meshheading:20952536-Melanocytes, pubmed-meshheading:20952536-Mice, pubmed-meshheading:20952536-Mice, Inbred C57BL, pubmed-meshheading:20952536-Microphthalmia-Associated Transcription Factor, pubmed-meshheading:20952536-Phosphodiesterase 4 Inhibitors, pubmed-meshheading:20952536-Phosphodiesterase Inhibitors, pubmed-meshheading:20952536-Protein Binding, pubmed-meshheading:20952536-RNA Interference, pubmed-meshheading:20952536-Rolipram, pubmed-meshheading:20952536-Signal Transduction, pubmed-meshheading:20952536-Skin
pubmed:year	2010
pubmed:articleTitle	Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit.
pubmed:affiliation	Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02114, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural