| pubmed-article:20952199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C1096176 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C1159825 | lld:lifeskim |
| pubmed-article:20952199 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20952199 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:20952199 | pubmed:dateCreated | 2010-11-2 | lld:pubmed |
| pubmed-article:20952199 | pubmed:abstractText | In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms. | lld:pubmed |
| pubmed-article:20952199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20952199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20952199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20952199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20952199 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20952199 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:YunesRosendo... | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:NunesRicardo... | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:Creczynski-Pa... | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:ChiaradiaLoui... | lld:pubmed |
| pubmed-article:20952199 | pubmed:author | pubmed-author:WinterEvelynE | lld:pubmed |
| pubmed-article:20952199 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20952199 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20952199 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20952199 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20952199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20952199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20952199 | pubmed:pagination | 8026-34 | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:meshHeading | pubmed-meshheading:20952199... | lld:pubmed |
| pubmed-article:20952199 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20952199 | pubmed:articleTitle | Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death. | lld:pubmed |
| pubmed-article:20952199 | pubmed:affiliation | Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil. | lld:pubmed |
| pubmed-article:20952199 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20952199 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20952199 | lld:chembl |
