Source:http://linkedlifedata.com/resource/pubmed/id/20952199
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Chalcone,
http://linkedlifedata.com/resource/pubmed/chemical/Chalcones,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8026-34
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pubmed:meshHeading |
pubmed-meshheading:20952199-Antineoplastic Agents,
pubmed-meshheading:20952199-Apoptosis,
pubmed-meshheading:20952199-Caspase 3,
pubmed-meshheading:20952199-Cell Line, Tumor,
pubmed-meshheading:20952199-Chalcone,
pubmed-meshheading:20952199-Chalcones,
pubmed-meshheading:20952199-Humans,
pubmed-meshheading:20952199-Leukemia,
pubmed-meshheading:20952199-Mitochondria,
pubmed-meshheading:20952199-Oxidative Stress,
pubmed-meshheading:20952199-Reactive Oxygen Species
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pubmed:year |
2010
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pubmed:articleTitle |
Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death.
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pubmed:affiliation |
Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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