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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-10
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pubmed:abstractText |
Poor blood flow and hypoxia/ischemia contribute to many disease states and may also be a factor in the decline of physical and cognitive function in aging. Nitrite has been discovered to be a vasodilator that is preferentially harnessed in hypoxia. Thus, both infused and inhaled nitrite are being studied as therapeutic agents for a variety of diseases. In addition, nitrite derived from nitrate in the diet has been shown to decrease blood pressure and improve exercise performance. Thus, dietary nitrate may also be important when increased blood flow in hypoxic or ischemic areas is indicated. These conditions could include age-associated dementia and cognitive decline. The goal of this study was to determine if dietary nitrate would increase cerebral blood flow in older adults.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1089-8611
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pubmed:author |
pubmed-author:BechtoldErikaE,
pubmed-author:BurdetteJonathan HJH,
pubmed-author:ClodfelterWilliamW,
pubmed-author:DoveRobin WRW,
pubmed-author:JenningsJanine MJM,
pubmed-author:Kim-ShapiroDaniel BDB,
pubmed-author:KingS BruceSB,
pubmed-author:KraftRobert ARA,
pubmed-author:LaurientiPaul JPJ,
pubmed-author:MillerGary DGD,
pubmed-author:MorganAshley RAR,
pubmed-author:PresleyTennille DTD,
pubmed-author:RejeskiW JackWJ
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-42
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20951824-Age Factors,
pubmed-meshheading:20951824-Aged,
pubmed-meshheading:20951824-Aged, 80 and over,
pubmed-meshheading:20951824-Analysis of Variance,
pubmed-meshheading:20951824-Brain,
pubmed-meshheading:20951824-Dietary Supplements,
pubmed-meshheading:20951824-Humans,
pubmed-meshheading:20951824-Magnetic Resonance Imaging,
pubmed-meshheading:20951824-Nitrates,
pubmed-meshheading:20951824-Nitrites,
pubmed-meshheading:20951824-Regional Blood Flow
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pubmed:year |
2011
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pubmed:articleTitle |
Acute effect of a high nitrate diet on brain perfusion in older adults.
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pubmed:affiliation |
Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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