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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-11-15
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pubmed:abstractText |
The eyes are rich in long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic acid [ARA; 20:4 (n-6)] and docosahexaenoic acid [DHA; 22:6 (n-3)]. Despite their abundance in the eyes, ARA and DHA cannot be sufficiently synthesized de novo in mammals. During gestation, eye development is exceptionally rapid, and substantial amounts of LC-PUFAs are needed to ensure proper eye development. Here, we studied the influences of dietary LC-PUFAs in dams (C57BL/6 and C3H/He) on the eye morphogenesis and organogenesis of their pups. Intriguingly, fetuses and newborn mice from C57BL/6 dams fed an LC-PUFA (particularly ARA)-enriched diet displayed a much higher incidence of eye abnormalities such as microphthalmia (small eye) and corneal opacity than those from dams fed an LC-PUFA-poor diet. The effects of LC-PUFAs on eye anomalies were evident only in the female pups of C57BL/6 inbred mice, not in those of C3H/He mice or male C57BL/6 mice. These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving ARA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1090-2104
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pubmed:author |
pubmed-author:ArugaJunJ,
pubmed-author:HamazakiKeiK,
pubmed-author:IwayamaYoshimiY,
pubmed-author:MaekawaMotokoM,
pubmed-author:NozakiYayoiY,
pubmed-author:OhbaHisakoH,
pubmed-author:OhnishiTetsuoT,
pubmed-author:OsumiNorikoN,
pubmed-author:ToyoshimaManabuM,
pubmed-author:WatanabeAkikoA,
pubmed-author:YoshikawaTakeoT
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
402
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
431-7
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pubmed:meshHeading |
pubmed-meshheading:20951676-Animals,
pubmed-meshheading:20951676-Arachidonic Acid,
pubmed-meshheading:20951676-Diet,
pubmed-meshheading:20951676-Docosahexaenoic Acids,
pubmed-meshheading:20951676-Eating,
pubmed-meshheading:20951676-Eye,
pubmed-meshheading:20951676-Eye Abnormalities,
pubmed-meshheading:20951676-Eye Proteins,
pubmed-meshheading:20951676-Female,
pubmed-meshheading:20951676-Homeodomain Proteins,
pubmed-meshheading:20951676-Male,
pubmed-meshheading:20951676-Mice,
pubmed-meshheading:20951676-Mice, Inbred C57BL,
pubmed-meshheading:20951676-Paired Box Transcription Factors,
pubmed-meshheading:20951676-Repressor Proteins,
pubmed-meshheading:20951676-Sex Factors,
pubmed-meshheading:20951676-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice.
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pubmed:affiliation |
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351-0198, Japan. mmaekawa@brain.riken.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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