Linked Life Data

20951638

Source:http://linkedlifedata.com/resource/pubmed/id/20951638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-11-24
pubmed:abstractText
During chronic infection of the cystic fibrosis (CF) lung, Pseudomonas aeruginosa grows and persists in a microaerobic to anaerobic environment. P. aeruginosa is well adapted to thrive under such conditions and contains multiple enzyme systems for energy generation under oxygen-restricted or even anaerobic conditions. Recent data confirm a heterogeneous environment in the CF lung and indicate that P. aeruginosa induces enzyme systems for microaerobic growth but also denitrification and fermentative pathways. Moreover, stress response systems as universal stress proteins enhance survival under anaerobic energy starvation conditions. Growth in these oxygen-limited environments induces a drastic physiological change in P. aeruginosa, like increased alginate production and alterations in the outer membrane, which contribute to an increased antibiotic tolerance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1618-0607
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier GmbH. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
300
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-56
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung.
pubmed:affiliation
Institute of Microbiology, Technische Universität Braunschweig, Germany. m.schobert@tu-bs.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't