| pubmed-article:20951583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C0003211 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C0008801 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C2266853 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:20951583 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:20951583 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:20951583 | pubmed:dateCreated | 2010-11-8 | lld:pubmed |
| pubmed-article:20951583 | pubmed:abstractText | Malaria is the most lethal parasite-mediated tropical infectious disease, killing 1-2 million people each year. An emerging drug target is the enzyme Plasmodium falciparum histone deacetylase 1 (PfHDAC1). We report 26 compounds designed to bind the zinc and exterior surface around the entrance to the active site of PfHDAC1, 16 displaying potent in vitro antimalarial activity (IC(50)<100 nM) against P. falciparum. Selected compounds were shown to cause hyperacetylation of P. falciparum histones and be >10-fold more cytotoxic towards P. falciparum than a normal human cell type (NFF). Twenty-two inhibitors feature cinnamic acid derivatives or non-steroidal anti-inflammatory drugs (NSAIDs) as HDAC-binding components. A homology model of PfHDAC1 enzyme gives new insights to interactions likely made by some of these inhibitors. Results support PfHDAC1 as a promising new antimalarial drug target. | lld:pubmed |
| pubmed-article:20951583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20951583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20951583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20951583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20951583 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20951583 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:ReidRobert... | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:FairlieDavid... | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:AndrewsKather... | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:LuckeAndrew... | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:WheatleyNicol... | lld:pubmed |
| pubmed-article:20951583 | pubmed:author | pubmed-author:TranTruc LTL | lld:pubmed |
| pubmed-article:20951583 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20951583 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20951583 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20951583 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20951583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20951583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20951583 | pubmed:pagination | 7080-4 | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:meshHeading | pubmed-meshheading:20951583... | lld:pubmed |
| pubmed-article:20951583 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20951583 | pubmed:articleTitle | Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. | lld:pubmed |
| pubmed-article:20951583 | pubmed:affiliation | Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia. | lld:pubmed |
| pubmed-article:20951583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20951583 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20951583 | lld:chembl |
