Source:http://linkedlifedata.com/resource/pubmed/id/20951162
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-12-21
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| pubmed:abstractText |
In this study, 5-flurouracil loaded fibrinogen nanoparticles (5-FU-FNPs) were prepared by two step coacervation method using calcium chloride as cross-linker. The prepared nanoparticles were characterized using DLS, SEM, AFM, FT-IR, TG/DTA and XRD studies. Particle size of 5-FU-FNPs was found to be 150-200 nm. The loading efficiency (LE) and in vitro drug release was studied using UV spectrophotometer. The LE of FNPs was found to be ?90%. The cytotoxicity studies showed 5-FU-FNPs were toxic to MCF7, PC3 and KB cells while they are comparatively non toxic to L929 cells. Cellular uptake of Rhodamine 123 conjugated 5-FU-FNPs was also studied. Cell uptake studies demonstrated that the nanoparticles are inside the cells. These results indicated that FNPs could be useful for cancer drug delivery.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1879-0003
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
98-105
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| pubmed:meshHeading |
pubmed-meshheading:20951162-Animals,
pubmed-meshheading:20951162-Antineoplastic Agents,
pubmed-meshheading:20951162-Cattle,
pubmed-meshheading:20951162-Cell Death,
pubmed-meshheading:20951162-Cell Line, Tumor,
pubmed-meshheading:20951162-Drug Delivery Systems,
pubmed-meshheading:20951162-Fibrinogen,
pubmed-meshheading:20951162-Fluorouracil,
pubmed-meshheading:20951162-Humans,
pubmed-meshheading:20951162-Light,
pubmed-meshheading:20951162-Microscopy, Fluorescence,
pubmed-meshheading:20951162-Nanoparticles,
pubmed-meshheading:20951162-Particle Size,
pubmed-meshheading:20951162-Rhodamines,
pubmed-meshheading:20951162-Scattering, Radiation,
pubmed-meshheading:20951162-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:20951162-Static Electricity,
pubmed-meshheading:20951162-Temperature,
pubmed-meshheading:20951162-X-Ray Diffraction
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| pubmed:year |
2011
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| pubmed:articleTitle |
5-fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications.
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| pubmed:affiliation |
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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