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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
The backup pathway of nonhomologous end joining (B-NHEJ) enables cells to process DNA double-strand breaks (DSBs) when the DNA-PK-dependent pathway of NHEJ (D-NHEJ) is compromised. Our previous results show marked reduction in the activity of B-NHEJ when LIG4(-/-) mouse embryo fibroblasts (MEFs) cease to grow and enter a plateau phase. The dependence of B-NHEJ on growth state is substantially stronger than that of D-NHEJ and points to regulatory mechanisms or processing determinants that require elucidation. Because the different D-NHEJ mutants show phenotypes distinct in their details, it is necessary to characterize the dependence of their DSB repair capacity on growth state and to explore species-specific responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-355X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
540-8
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pubmed:meshHeading |
pubmed-meshheading:20950945-Androstadienes,
pubmed-meshheading:20950945-Animals,
pubmed-meshheading:20950945-CHO Cells,
pubmed-meshheading:20950945-Cell Cycle,
pubmed-meshheading:20950945-Cell Growth Processes,
pubmed-meshheading:20950945-Cell Survival,
pubmed-meshheading:20950945-Cricetinae,
pubmed-meshheading:20950945-Cricetulus,
pubmed-meshheading:20950945-DNA Breaks, Double-Stranded,
pubmed-meshheading:20950945-DNA Repair,
pubmed-meshheading:20950945-DNA-Activated Protein Kinase,
pubmed-meshheading:20950945-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:20950945-Fluorescent Antibody Technique,
pubmed-meshheading:20950945-Histones,
pubmed-meshheading:20950945-Humans,
pubmed-meshheading:20950945-Mice,
pubmed-meshheading:20950945-Mutation,
pubmed-meshheading:20950945-Protein Kinase Inhibitors,
pubmed-meshheading:20950945-Species Specificity,
pubmed-meshheading:20950945-Terminology as Topic
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pubmed:year |
2011
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pubmed:articleTitle |
Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors.
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pubmed:affiliation |
Institute of Medical Radiation Biology, University Duisburg-Essen Medical School, Essen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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