Source:http://linkedlifedata.com/resource/pubmed/id/20950730
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2010-10-18
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| pubmed:abstractText |
Topoisomerases are ubiquitous nuclear enzymes that regulate DNA structure in eukaryotic cells. The role of topoisomerase III?, the newest member of the topoisomerase family, in the clinical outcome of breast cancer is still poorly understood. This study aims to investigate the immunoexpression of topoisomerase III? in breast cancer and its relationships with clinicopathologic features and immunohistochemical markers of prognostic significance in breast pathology. Using tissue microarrays containing 171 cases of primary invasive breast cancer, we analyzed the immunoexpression of topoisomerase III?, estrogen receptor, progesterone receptor, HER-2, BRCA-1, p53, and Ki67. Immunostaining for topoisomerase III? was found in 33.9% of breast carcinomas, and immunopositivity was correlated with distant metastasis (P = .036) and death (P = .006). Decreased expression of topoisomerase III? correlated with low expression of Ki67 (P < .001) and negativity for HER-2 (P < .001), BRCA-1 (P = .001), and p53 (P < .001). In the multivariate analysis, topoisomerase III? expression was a significant predictor of survival (hazard ratio, 3.006 [95% confidence interval, 1.582-5.715]; P = .001). In conclusion, topoisomerase III? expression can be a useful marker in assessing the prognosis of patients with breast cancer and is an independent predictor of survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1532-8392
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| pubmed:author |
pubmed-author:GarciaSérgio BrittoSB,
pubmed-author:Oliveira-CostaJoão PauloJP,
pubmed-author:OliveiraLucinei RobertoLR,
pubmed-author:RamalhoLeandra ZambelliLZ,
pubmed-author:Ribeiro-SilvaAlfredoA,
pubmed-author:Silva RamalhoFernandoF,
pubmed-author:SoaresFernando AugustoFA,
pubmed-author:ZanettiJulianaJ
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| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
41
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1624-30
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| pubmed:meshHeading |
pubmed-meshheading:20950730-Adult,
pubmed-meshheading:20950730-Aged,
pubmed-meshheading:20950730-Aged, 80 and over,
pubmed-meshheading:20950730-Brazil,
pubmed-meshheading:20950730-Breast Neoplasms,
pubmed-meshheading:20950730-Carcinoma, Ductal, Breast,
pubmed-meshheading:20950730-Combined Modality Therapy,
pubmed-meshheading:20950730-Cytogenetic Analysis,
pubmed-meshheading:20950730-DNA Topoisomerases, Type I,
pubmed-meshheading:20950730-Female,
pubmed-meshheading:20950730-Humans,
pubmed-meshheading:20950730-In Situ Hybridization,
pubmed-meshheading:20950730-Isoenzymes,
pubmed-meshheading:20950730-Middle Aged,
pubmed-meshheading:20950730-Neoplasm Metastasis,
pubmed-meshheading:20950730-Neoplasm Staging,
pubmed-meshheading:20950730-Prognosis,
pubmed-meshheading:20950730-Survival Rate,
pubmed-meshheading:20950730-Tissue Array Analysis,
pubmed-meshheading:20950730-Tumor Markers, Biological,
pubmed-meshheading:20950730-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Significance of topoisomerase III? expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis.
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| pubmed:affiliation |
Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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