Source:http://linkedlifedata.com/resource/pubmed/id/20949916
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2010-11-29
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pubmed:abstractText |
A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B-E (2-4, 7), 3-acetyleriocasin C (5), and 3?-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A-F (8, 10-14) and 3?-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC(50) values in the range 2.1-7.3 ?M.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1520-6025
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pubmed:author |
pubmed-author:HeFeiF,
pubmed-author:HuangSheng-XiongSX,
pubmed-author:JinXiao-LingXL,
pubmed-author:LiLi-MeiLM,
pubmed-author:LouLi-GuangLG,
pubmed-author:PuJian-XinJX,
pubmed-author:RéauRR,
pubmed-author:SunHan-DongHD,
pubmed-author:ToYenY,
pubmed-author:XiaoWei-LieWL,
pubmed-author:ZhangMeiM,
pubmed-author:ZhaoBoB
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1803-9
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pubmed:meshHeading |
pubmed-meshheading:20949916-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:20949916-Diterpenes,
pubmed-meshheading:20949916-Drug Screening Assays, Antitumor,
pubmed-meshheading:20949916-Humans,
pubmed-meshheading:20949916-Inhibitory Concentration 50,
pubmed-meshheading:20949916-Isodon,
pubmed-meshheading:20949916-Molecular Structure,
pubmed-meshheading:20949916-Nuclear Magnetic Resonance, Biomolecular
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pubmed:year |
2010
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pubmed:articleTitle |
Structure and cytotoxicity of diterpenoids from Isodon eriocalyx.
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pubmed:affiliation |
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
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pubmed:publicationType |
Journal Article
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