Linked Life Data

20948451

Source:http://linkedlifedata.com/resource/pubmed/id/20948451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2010-11-3
pubmed:abstractText
RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1473-558X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1080-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
No link of serotonin 2C receptor editing to serotonin transporter genotype.
pubmed:affiliation
James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA
pubmed:publicationType
Journal Article, Comparative Study