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rdf:type |
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lifeskim:mentions |
umls-concept:C0025723,
umls-concept:C0069225,
umls-concept:C0227349,
umls-concept:C0678226,
umls-concept:C1261552,
umls-concept:C1334505,
umls-concept:C1457869,
umls-concept:C1511681,
umls-concept:C1521738,
umls-concept:C1527148,
umls-concept:C1527249,
umls-concept:C1704410,
umls-concept:C1881865,
umls-concept:C1998548
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-15
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pubmed:abstractText |
O(6)-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O(6)-guanine. Known as methylation tolerance, selection for mismatch repair (MMR)-deficient cells that are unable to initiate lethal processing of O(6)-methylguanine-induced mismatches in DNA is observed in vitro as a consequence of MGMT deficiency. It was therefore hypothesised that an MGMT field defect may constitute a preneoplastic event for the development of MMR-deficient tumours displaying microsatellite instability (MSI).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/O(6)-Methylguanine-DNA...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1468-3288
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pubmed:author |
pubmed-author:BuhardOlivierO,
pubmed-author:ColasChrystelleC,
pubmed-author:ColluraAdaA,
pubmed-author:CosnesJacquesJ,
pubmed-author:CouletFlorenceF,
pubmed-author:DumontSylvieS,
pubmed-author:DuvalAlexA,
pubmed-author:FléjouJean-FrançoisJF,
pubmed-author:GaubMarie-PierreMP,
pubmed-author:HamelinRichardR,
pubmed-author:LascolsOlivierO,
pubmed-author:LegrainMichèleM,
pubmed-author:MassaoudiIlliasseI,
pubmed-author:OliveiraCarlaC,
pubmed-author:PujoLucieL,
pubmed-author:SerucaRaquelR,
pubmed-author:SvrcekMagaliM,
pubmed-author:TiretEmmanuelE
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1516-26
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pubmed:meshHeading |
pubmed-meshheading:20947886-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:20947886-Adult,
pubmed-meshheading:20947886-Aged,
pubmed-meshheading:20947886-Aged, 80 and over,
pubmed-meshheading:20947886-Colorectal Neoplasms,
pubmed-meshheading:20947886-DNA, Neoplasm,
pubmed-meshheading:20947886-DNA Methylation,
pubmed-meshheading:20947886-DNA Mismatch Repair,
pubmed-meshheading:20947886-Female,
pubmed-meshheading:20947886-Humans,
pubmed-meshheading:20947886-Intestinal Mucosa,
pubmed-meshheading:20947886-Male,
pubmed-meshheading:20947886-Microsatellite Instability,
pubmed-meshheading:20947886-Middle Aged,
pubmed-meshheading:20947886-Mutation,
pubmed-meshheading:20947886-Neoplasm Staging,
pubmed-meshheading:20947886-Nuclear Proteins,
pubmed-meshheading:20947886-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:20947886-Precancerous Conditions,
pubmed-meshheading:20947886-Promoter Regions, Genetic,
pubmed-meshheading:20947886-Proto-Oncogene Proteins,
pubmed-meshheading:20947886-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:20947886-Young Adult,
pubmed-meshheading:20947886-ras Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.
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pubmed:affiliation |
Equipe Instabilité des Microsatellites et Cancers, Hôpital Saint-Antoine, Paris cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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